SARS-CoV-2 Seroprevalence in Healthcare Workers of Kaunas Hospitals during the First Wave of the COVID-19 Pandemic
SARS-CoV-2 Seroprevalence in Healthcare Workers of Kaunas Hospitals during the First Wave of the COVID-19 Pandemic
Blog Article
Background and objective: Serologic testing is a useful additional method for the diagnosis of COVID-19.It is also used for population-based seroepidemiological studies.The objective of the study was to determine SARS-CoV-2 seroprevalence in healthcare workers of Kaunas hospitals and to compare two methods for LEISURE COOKMASTER CK100G232K 100CM FULL GAS RANGE COOKER LPG CONVERTIBLE BLACK specific SARS-CoV-2 antibody testing.Materials and Methods: A total of 432 healthcare workers in Kaunas hospitals were enrolled in this study.Each participant filled a questionnaire including questions about their demographics, contact with suspected or confirmed COVID-19, acute respiratory symptoms, and whether they contacted their general practitioner, could not come to work, or had to be hospitalized.
Capillary blood was used to test for SARS-CoV-2 specific immunoglobulin G (IgG) and immunoglobulin M (IgM) a lateral flow immunoassay.Serum samples were used to test for specific IgG and IgA class immunoglobulins using semiquantitative enzyme-linked immunosorbent assay (ELISA) method.Results: 24.77% of study participants had direct contact with a suspected or confirmed case of COVID-19.A total of 64.
81% of studied individuals had at least one symptom representing acute respiratory infection, compatible with COVID-19.Lateral flow immunoassay detected SARS-CoV-2 specific IgG class immunoglobulins in 1.16% of the tested group.Fever, cough, dyspnea, nausea, diarrhea, headache, conjunctivitis, muscle pain, and loss of smell and taste predominated in the anti-SARS-CoV-2 IgG-positive group.Using ELISA, specific IgG were detected in 1.
32% of the tested samples.Diarrhea, loss of appetite, and loss of smell and taste sensations were the most predominant symptoms in anti-SARS-CoV-2 IgG-positive group.The positive percent agreement of the two testing methods was 50%, and negative percent agreement was 99.66%.Conclusions: 1.
16% of tested healthcare workers of Kaunas hospitals were anti-SARS-CoV-2 IgG-positive.The Panama Hat negative percent agreement of the lateral flow immunoassay and ELISA exceeded 99%.